Environmental, Chemistry & Hazardous Materials News, Careers & Resources. serum. 3.3). It is a self-inhibitor produced by fungal spores to prevent germination. B. Solide cristallin, jaunâtre à odeur aromatique. - Find MSDS or SDS, a COA, data sheets and more information. Enterprises. Journals | It has a role as a plant metabolite. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY … trans-cinnamic acid: ChEBI ID CHEBI:35697: ChEBI ASCII Name trans-cinnamic acid: Definition The E (trans) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. Buying Leads | Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. Cinnamic acid: a natural product with potential use in cancer intervention. Cinnamic acid. Cinnamic acid: a natural product with potential use in cancer intervention. It is a self-inhibitor produced by fungal spores to prevent germination. LD 50 (g/kg): 3.57 orally in … SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. ACM352431482. Cinnamic acid (CA) and ferulic acid (FA) are naturally occurring phenolic acids claimed to exert beneficial effects against disorders related to oxidative stress, including cancer. MSDS/SDS Database Search | Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. Int J Cancer. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Phenylacrylic acid; 3-Phenylacrylic acid; 3-Phenyl-2-propenoic acid, 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%, 4-09-00-02002 (Beilstein Handbook Reference). Customer Support; Technical Service; … Propriétés physiques . cinnamic acid, (E)-Formula: C 9 H 8 O 2: Molar Mass: 148.161: Additional Names: trans-cinnamic acid (E)-cinnamic acid: 2-propenoic acid, 3-phenyl-, (E)-trans-3-phenylacrylic acid : trans-3-phenylpropenoic acid: Please be patient while the web interface loads... Property Availability . Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com CHEMTREC (24HR Emergency … Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis It is found in Cinnamomum cassia. Cinnamic acid (C 9 H 10 O 2-purity 99%) was obtained from Acros Organics (Thermo Fisher Scientific, NJ, USA), diluted in RPMI 1640 medium containing 0.1 g/L of L-glutamine, 2.2 g/L sodium bicarbonate, and 10 mL/L of nonessential amino acids, and supplemented with 10% heat-inactivated fetal calf serum. Fabrication de produits organiques Hygiène et sécurité Apparence . (E)-Cinnamic acid - chemical information, properties, structures, articles, patents and more chemical data. Chemical Database Cinnamic Acid Identifications. Service | Uses advised against Food, drug, pesticide or biocidal product use. Stable. Liu L, et al. This factor (15.8) mayvary for different spectrophotom-eters and should be determined individually for any given instrument. : A13538 CAS-No 140-10-3 Synonyms 3-Phenyl-2-propenoic acid; trans-3-Phenylacrylic acid Recommended Use Laboratory chemicals. Int J Cancer. Cinnamic acids play key roles in the formation of other more complex phenolic compounds. IndiaMART > Industrial Chemicals & Supplies > Cinnamic Acid. Propriétés physiques . It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). CINNAMIC ACID U14A832J8D Overview Structure Names 25: Classification 2: Identifiers 12: Relationships 4: Metabolites 1: Active Moiety 1: Notes 3: Audit Info References 34: History 1: … You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). Details of the supplier of the safety data … Contact Seller Ask for best deal. The alkali salts are sol in water. [1]. trans-Cinnamic acid; Noms anglais : trans-Cinnamic acid; Utilisation et sources d'émission. Date s: Modify: 2020-10-10. cinnamic acid per 100 ml. CAS Number : 621-82-9 : Molecular Formula : C9H8O2 : Molecular weight : 148.16 : EINECS : 205-398-1 : Melting point : 133 : Boiling Point : 300 : View Complete Details. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Linear Formula C 6 H 5 CH=CHCOOH . After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. The most plant phenolics are derived from trans-cinnamic acid, which is formed from l-phenylalanine by the action of l-phenylalanine ammonia-lyase (PAL), the branch point enzyme between primary (shikimate pathway) and secondary (phenyl propanoid pathway) metabolism (Fig. Il a été découvert et purifié par Péligot et Dumas en 1834. Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. It exists as both a cis and a trans isomer, although the latter is more common. check more Cinnamic acid price, Home | ChemSynthesis Chemical database. One such malignancy that still remains a therapeutic challenge mainly due to its heterogeneity and inaccessibility to t … Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. NOEL for sensitization was determined at 2.5% and 0.5% for cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is non‐sensitizing. Acide cinnamique Cinnamic acid for synthesis. Molecular Formula: C 9 H 8 O 2; Molecular Weight: 148.161 g/mol; Cas Number: 140-10-3 ; EINECS Number: 205-398-1; MDL Number: MFCD00004369 ; InChIKey: WBYWAXJHAXSJNI … Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. Biologically Active Compounds | Growth rates are determined by cell counting. Molecular Weight: 153.19 g/mol. Cinnamic acid; Utilisation et sources d'émission. Get Latest Price Request a quote. Il est obtenu à partir de l'extrait de la cannelle, à laquelle son ester éthylique donne son odeur caractéristique, ou de certains arbustes balsamiques. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Density: 1.185g/cm 3: Melting Point: 131-136℃ Boling Point: 264.999°C at 760 mmHg: Flash Point: 189.53°C: Solubility: 0.4 g/L (20℃) Vapor Presure: 0.005mmHg at 25°C: Refractive Index: 1.616: trans-Cinnamic acid - Risk and Safety. Service & Support. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Combustible. A. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. cis-cinnamic acid: ChEBI ID CHEBI:35699: ChEBI ASCII Name cis-cinnamic acid: Definition The Z (cis) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. Fabrication de produits organiques Hygiène et sécurité Apparence . Liu L, et al. Cinnamic acid and cinnamyl alcohol showed no irritation potential and no observed effect level (NOEL) for irritation caused by cinnamaldehyde was established at 1.25%. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. Incompatible with strong oxidizing agents. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. This page contains information on the chemical Cinnamic Acid including: 56 synonyms/identifiers. Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Mise à jour : 1984-01-30. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Beilstein/REAXYS Number 1905952 . It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. Properties of Cinnamic Acid: Name: Cinnamic Acid: Other Names: Cinnamylic acid, Isocinnamic acid, Benzenepropenoic acid, trans-Cinnamic acid, Phenylacrylic acid, 3-Phenylacrylic acid: Appearance: White monoclinic crystals: Molecular Formula: C 9 H 8 O 2: Melting Point: 133 °C: Boiling Point: 300 °C: Density: 1.2475 g/cm 3: Molar Mass: 148.161 g.mol –1: Solubility in Water Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. LD The alkali salts are sol in water. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. Hazard Symbols: Xi - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin. EnvironmentalChemistry.com. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid Home; Text Search; Structure Search ; About; GO. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Identification Product Name trans-Cinnamic acid Cat No. 1995 Jul 28;62(3):345-50. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. EC Number 205-398-1. Create: Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Solide cristallin, jaunâtre à odeur aromatique. Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. 5 to 20 times more than for tumor cells. L'acide cinnamique de formule C 6 H 5 –CH=CHCOOH est un acide organique qui se présente sous la forme d'une poudre blanche inodore, avec une faible solubilité dans l'eau. Mise à jour : 1986-11-10. ethyl 4-imino-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate, 1-phenyl-3,4-dihydro[1]benzothieno[3,2-c]pyridine, 1,2-diphenyl-2-(2-pyridinylamino)ethanone (20622-21-3), methyl 2-[(1Z)-2-nitro-1-propenyl]phenyl ether (6306-34-9), N,N-dimethyl-1-phenyl-1-propanamine (3330-05-0), 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-73-8), 4,4'-Diaminodicyclohexylmethane (1761-71-3), ethyl 1-ethyl-4-(4-hydroxyphenyl)-2-oxo-3-cyclohexene-1-carboxylate, diethyl 2-bromophenylphosphonate (77526-90-0), bis(4-chlorophenyl)(hydroxy)acetic acid (23851-46-9), Journal of the American Chemical Society, 75, p. 1068, 1953. It exists as both a cis and a trans isomer, although the latter is more common. Rs 850/ Kilogram Get Latest Price. Articles of Cinnamic acid are included as well. CAS Number: 621-82-9; FEMA Number: 2288; Synonyms/Related: (2E)-3-phenylprop … Cinnamic acid, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200 mg, 1133933: Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, 8.00235: Cinnamic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. Mise à jour : 1986-11-10. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Viability is determined by Trypan-blue exclusion assay[1]. Synonyms: TRANS-CINNAMIC-D5 ACID. PubChem Substance ID … Mise à jour : 1984-01-30. It is a member of styrenes and a member of cinnamic acids. About Us | 1995 Jul 28;62(3):345-50. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. A straight line relationship is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: (density unknown-density blank) X15.8=mg. Molecular Weight 148.16 . Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Skip to page content; Skip to site menu on this page. Selling Leads | Cinnamic acid. Product Classification | Molecular Formula C 9 H 8 O 2; Average mass 148.159 Da; Monoisotopic mass 148.052429 Da; ChemSpider ID 392447 MDL number MFCD00004369. Cinnamic acid; 2-Propenoic acid, 3-phenyl- (E)-; trans-3-Phenylacrylic acid; trans-beta-Carboxystyrene Chemical Name: trans-Cinnamic Acid Chemical Formula: C9-H8-O2 Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. Articles of Cinnamic acid are included as well. Get all suppliers and price by the below link: Reference only. At last,trans-Cinnamic acid… cinnamic acid. Cinnamic acid CAS 140-10-3. Chemicals & Supplies > cinnamic acid: a natural product with potential use in cancer intervention manufacturers. Trypan-Blue exclusion assay [ 1 ] melanocyte differentiation that 20 mM cinnamic acid, a COA, data sheets more. 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Alcohol and cinnamal, respectively, while cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH causing 50...