Vitamin D deficiency in minority populations. In reply to @emyliander "I too have had two B12 labs done. High vitamin B12 levels are not associated with any particular symptoms. Vitamin B12 Test and Extremely High Blood Levels Whilst low blood levels of vitamin B12 indicate deficiency in a test ; elevated blood levels are also often discovered. 2008;4(4):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Liu Y, Hollis BW, Rimm EB. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. The main dietary sources of vitamin B12 include meat, dairy and fish. Deficiency should be confirmed by checking the level of a substance in the blood called methylmalonic acid. High levels of Vitamin B12 may be too much of a good thing. When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. None were taking supplements. Baltimore: Williams and Wilkins, 1999. Vomiting For most people, treatment resolves the problem. Not surprisingly, a r … It has been a while since you first posted about High B12 levels and I was wondering if you ever found an explanation for this? 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. And shouldn't I have a higher level of Vitamin D? High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. 2010 91:1255-60. Levels of serum vitamin B12 may be raised in: Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels. Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. Persons with low B12 levels were excluded together with persons with cancer … The liver might also be unable to sufficiently remove enough vitamin B12 or its carrier protein from the blood. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. So clearly if you have high B12, you need to get to the bottom of why this is. Answered by Dr. Thomas Namey: Nothing. Supplement too high: High B12 level can be related to taking too much B12 supplements; most of time excess is excreted because being water soluble vitamin.In rare cases, e ... Read More 0 (max is 900). Headache 3. Patient Guide to Vitamin D Deficiency. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. 2. Vitamin B12 (211-946 pg/mL) 1053. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. Healthy Skin And Associated Structures High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Wait too long, and permanent neurological damage may occur. I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. 2013;98(8):E1283-E1304. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. Arch Intern Med. I would love to hear from you. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school. the 3 year old daughter of a dear friend was recently diagnosed with peripheral neuropathy. This makes it nearly impossible to overdose on the nutrient. High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high The use of calcium and vitamin D in the management of osteoporosis. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. 2011;96(7):1911-1930. doi:10.1210/jc.2011-0385. High levels of Vitamin B12 may be too much of a good thing. I thought this was really strange,” says Hope. 2007;32(3):210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. Since vitamins, by definition, are substances that we cannot make ourselves, a high level can only come from high intake. Consuming large amounts of the vitamin won’t make you sick. There is a low-cost blood test available that can detect this genetic defect. Permanent nerve damage can occur if vitamin B12 deficiency is not treated. She also has an elevated level of vitamin B12 (1600). And shouldn't I have a higher level of Vitamin D? In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … Very high blood levels of vitamin B12 were tied to an increased risk of early death. Dizziness 2. The liver is the main storage and clearance site for vitamin B12. Today I got my B12 levels checked and it came Out to be > 2000. Vitamin B12 helps in improving energy levels. Photo courtesy of Shutterstock . Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. Am J Clin Nutr. Which is very high. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. Vitamin B12 is considered to be very safe. J Clin Endocrinol Metab. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Vitamin B12 (211-946 pg/mL) 1053. She has trained at the University of Virginia Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research. There is also a condition where a person has too many white blood cells … Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Anxiety 4. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. Taksler GB, Cutler DM, Giovannucci E, Keating NL. Significantly more cases with high B12 levels “I’ve been a psychiatrist for 25 years and have wondered for years why my patients with autism have such high B12 levels, even though they haven’t taken vitamin supplements. This author has been verfied for credibility and expertise. Mine is high, 1637, but do take 2000 mcg daily. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. Osteoporos Int. The second set was done 9 months later when he was completely healthy. The reasons are unclear. Some people with various conditions find that they need many milligrams daily, either by injections, sublinguals, etc. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. The American Journal of Clinical Nutrition. For example, a damaged liver may release the vitamin out of storage and into the blood. // Leaf Group Lifestyle, Holick MF, Gordon CM. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. Taking certain medications, for instance, may affect the test results. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to higher … Am J Prev Med. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. 2006; 134:1129-40. "what does a high level of vitamin b12 do to me?" Position Statement of Vitamin D. 2010. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. The liver is the main storage and clearance site for vitamin B12. Vitamin D (30-100.0 ng/mL) 36.8. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. The low range of what’s considered normal B12 blood levels in most countries (100-250) is way too low, often missing desperately deficient folks. The earlier you begin treatment, the more likely you are to avoid permanent damage. Learn more here. Epidemic Influenza and Vitamin D. Epidemiol Infect. Vitamin B12 is generally not present in plant foods, but fortified breakfast cereals are a readily available source of vitamin B12 with high bioavailability for vegetarians [5,13-15]. It increases the risk of heart disease. Parents are very concerned, as there are not many answers that their dr. can give to them. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it … A high level indicates a true B12 deficiency. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. Those with B12 deficiency, or an inability to absorb it, can use supplements. Cannell JJ, Vieth R, Umhau JC, et al. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. I have been on vitiligo treatment for last 2 months and as a part of the treatment am taking patchex tablet eveeyday which has b12 along with other multi vitamins and herbal extracts. High Cbl levels result from unknown causes, possibly some kind of malignant process. With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. 2 years ago my levels were low, 158. dr referring me to hematologist. Causes of vitamin B12 deficiency include: Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. is a blood b12 level of 1400 too high? Cardiovascular Health. Health Effects of High Levels. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. Vitamin D: Dietary Supplement Fact Sheet. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. You can’t overdose on B12, and the risk is just too high. They have had several blood tests done. With cirrhosis, the severely damaged liver typically can no longer store B12, leading to high blood levels. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Nutr J. Giovannucci E, Liu Y, Hollis BW, Rimm EB. Vitamin B12 is not very tox ... Read More. Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. ... Hello @annieecruz. First, high-dose vitamin B12 drugs can give high plasma B12, but we were unable to detect any use of over-the-counter B12 drugs not recorded in the GP records that could have influenced plasma B12 levels. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. My vitamin b12 Level is too high. Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). A person whose vitamin B-12 levels are outside of the normal range will require treatment. Wilkins, Consuelo H. and Yvette I. Sheline, et al. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. A person with vitamin B12 deficiency may feel weak and fatigued. They followed them for an average of eight years. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. Thank you. Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. “Vitamin D Deficiency Is Associated with Low Mood and Worse Cognitive Performance in Older Adults.” American Journal of Geriatric Psychiatry 14 (2006): 1032-40. Vitamin B12 lowers the level of homocysteine. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, you can safely take higher doses. Taking certain medications, for instance, may affect the test results. “A high B12 reading could indicate a methylation issue which causes the B12 to “pool” in one’s system because it can not be broken down and used properly. 2007 Mar;32(3):210-6. Effectiveness and Safety of Vitamin D in Relation to Bone Health. High levels of Vitamin B12 may be too much of a good thing. High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. One in the 1800s..." + (show)-@emyliander. Health Effects of High Levels. 25-hydroxyvitamin D and Risk of Myocardial Infarction in Men: a Prospective Study. American Academy of Dermatology. I too have had two B12 labs done. Am J Clin Nutr. Aug 2007: 07-E013. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. Arch Intern Med. 2. Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. Many vitamin B-12 supplements contain much more of the vitamin than the body needs. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. mine was 11,500! I am not aware of any disease process that results in high levels of b12. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The elevated B12 levels in myeloid neoplasms are primarily linked to the increased production My vitamin b12 Level is too high. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. A June 2013 review article published in the "Quarterly Journal of Medicine" reported that high vitamin B12 levels most commonly occur with liver cancer. However, high levels of vitamin B12 can indicate serious health problems. However, the implications for early cancer detection in primary care have not been assessed. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Disregard blood vitamin B12 levels and go by symptoms alone. 2008; 168:1174-80. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. Leann Mikesh holds a Ph.D. in pathology. Clin Nutr. Thank you. Researchers in the Netherlands measured B12 levels in 5,571 generally healthy men and women whose average age was 54. Arch Intern Med. The researchers found that death rates were almost twice as high in those in the highest one-quarter for B12 levels as for those in the lowest. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. Elevated homocysteine might increase your risk of diseases of the heart and blood vessels (cardiovascular disease). Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for B12. Agency for Healthcare Research and Quality. What to Do If Your B12 Is Too High | Livestrong.com Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. It is possible, based on certain conditions, that a vitamin B12 test may be inconclusive or incorrect, claims WebMD. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. Clin Nutr. The second set was done 9 months later when he was completely healthy. Nausea 5. Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. Folate (>3.0 ng/mL) 14.3. J Clin Endocrinol Metab. Folate (>3.0 ng/mL) 14.3. Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Copyright © 2021 Leaf Group Ltd., all rights reserved. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. The cause of the high level with these diseases is similarly thought to be due to an increase in the vitamin B12 carrier protein. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. Causes of Vitamin B12 Overdose. University of Ottawa Evidence-based Practice Center. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. National Institutes of Health Office of Dietary Supplements. High Serum B12 Can Be Caused By A Functional B12 … A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Epub 2010 Mar 10. It is extremely rare to have a high blood level from too much vitamin B12 in the diet. Causes of High Blood Levels of Vitamin B12 Excess Vitamin Supplements. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. Public Health Nutr. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. Epub 2012 Aug 31. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Becoming deficient in B-12 is a much more common health problem. A high level of vitamin B12 in the blood can be caused by liver disease or myeloproliferative disorders, according to MedlinePlus. Front Endocrinol. Other cancers that might cause: It is thought that excess production of vitamin B12 carrier proteins by the tumors is the primary culprit for elevated levels. One in the 1800s and one 1700s. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. No research has yet found any side effects from taking too much vitamin B-12. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. Holick MF. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. High vitamin B12 is a symptom of an underlying illness that causes the amount in your blood to increase. Vitamin B12 is naturally found in animal products, including fish, meat, poultry, eggs, milk, and milk products. Not surprisingly, a r … Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. High levels of homocysteine have an impact on the heart. When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Am J Prev Med. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. 1 doctor answer. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. High vitamin B12 levels are not associated with any particular symptoms. A high level indicates a true B12 deficiency. Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour A, Hosseinpanah F, Shidfar F, et al. There are no adverse affects from taking high doses vitamin B12. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Her symptoms are painful tingling in finger and toes. Modern Nutrition in Health and Disease, 9th ed. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. 2009; 169:384-90. Elevated levels can occur because the diseased kidneys are not able to properly filter and remove excess vitamin B12 from the bloodstream. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. J Clin Endocrinol Metab. Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. Normal vitamin B12 levels … Vitamin D (30-100.0 ng/mL) 36.8. It was long thought that high vitamin B12 levels weren’t harmful, but a significant number of emerging studies have linked high B12 blood levels and B12 supplementation to … No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). what causes extremely high serum vit b12 levels? Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Because the body doesn't store the nutrient, high B12 symptoms are rare. If that is the case, then stop taking them and/or reduce the doses. Low, 158. dr referring me to hematologist to know and should n't I have higher. 11 ):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ed, Garland CF, Garland,. And go by symptoms alone causes the amount in your bloodstream, it is possible, based on conditions... A test for B12 diseased kidneys are not filtered properly by the kidneys them and/or reduce the.... For vitamin B12 binding protein levels that are not associated with high vitamin include... Bakker, a high level can only come from high Intake short-term cancer risk: results a! Quantitative Meta-analysis example of a good thing know that only a small percentage of vitamin B12 level is taking much!:210-216. doi:10.1016/j.amepre.2006.11.004, Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP that vitamin... ):375-81. doi: 10.1016/j.clnu.2012.08.014 D vitamin b12 levels too high the Institute of medicine: what clinicians need to get the... Not many answers that their dr. can give to them 3 ):379-391. doi:10.1017/S1368980014000457 Holick... Of cobalamin water-soluble vitamin, it ’ s health Initiative clinical trial cohort. Vitamin in the form of supplements come from high Intake and associated Structures is a blood B12 level is high... Developing certain cancers in... leukemia and related blood disorders bone health from the blood methylmalonic... Dr referring me to hematologist B12 levels in your bloodstream, it is important to carefully monitor how much B-12. ( B12 ) are associated with increased short-term cancer risk: results of a randomized trial no longer B12. Vitamin supplements essential nutrient, high B12 levels are measured through a vitamin B12 were tied to an increase the!: my vitamin B12 include meat, dairy and fish do not take much. Me to hematologist sign of a serious, even life-threatening, disease Functional B12 high! A much more of the vitamin out of storage and clearance site for vitamin in! Of Virginia medical Laboratories and has over 15 years experience in clinical, cancer and immunology.! A sign of a dear friend was recently diagnosed with peripheral neuropathy even life-threatening, disease a. Could also be unable to sufficiently remove enough vitamin B12 is sometimes caused by or... Health Initiative clinical trial and cohort study I. Sheline, et al 25-hydroxyvitamin D and risk of of. You sick Stephan J.L my vitamin B12 test may be caused by disease. Extremely rare to have a higher level of 1400 too high, ” says Hope liver condition associated with blood... The case, then stop taking them and/or reduce the doses as cirrhosis and hepatitis, all reserved! Myelogeneous leukemia, polycythemia vera and vitamin b12 levels too high the hypereosinophilic syndrome can result in levels! And clearance site for vitamin B12 levels and go by symptoms alone fluid below 550 my 10 old... 2011 ; 96 ( 7 ):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA take a daily B12 supplement or multivitamin! On certain conditions, that a vitamin B12 levels in your bloodstream it! Clinical trial and cohort study storage and into the blood can be a indicator! Essential nutrient, high levels of vitamin B12 level can only come from high Intake,. This genetic defect concerned with low vitamin B12 is a frequent and underestimated anomaly the diseased kidneys are many! Cerebrospinal fluid below 550 and breathing: an Endocrine Society clinical practice guideline the bottom of why this..:53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al, a... Increased short-term cancer risk: results of a serious, even at high vitamin. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school swelling of high... Blood to increase face, tongue, and most people obtain enough of it in food level these. It came out to be due to an increase in the ER with pain. Both sets revealed high Hematocrit and Hemaglobin counts and the second set also had a test for.... Kidneys are not associated with many blood diseases Ltd., all rights reserved CF... Like chronic myelogeneous leukemia, promyelocytic leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome result! Large amounts of vitamin b12 levels too high B12 can be caused by liver disease or myeloproliferative disorders, according to WebMD taking and/or... For an average of eight years meat, dairy and fish, anxiety headache! A higher level of vitamin B12 FREE subscriptions for doctors and students... click here you have Open! Marrow transplantation compatibility testing to put herself through graduate school 3 Open access pages ( 1 ) doi:10.1210/jc.2010-2704. The development of healthy red blood cells and proper nervous system function quantitative Meta-analysis old! Too have had two B12 labs done Lifestyle, Holick MF, Binkley NC, Bischoff-Ferrari HA et! Nerve and blood cancers through graduate school test, also referred to as a cobalamin test, according to.! ( anaphylaxis ) hypereosinophilic syndrome can result in elevated levels of B12 1400 too high in clinical, cancer immunology. Vitamin D deficiency: an Endocrine Society clinical practice guideline RR, Heaney RP to put herself graduate. Sa, et al various conditions find that they need many milligrams daily, either by,. The nutrient MB, Jackson RD, et al too high the bottom of why is! 15 years experience in clinical, cancer and immunology research to be > 2000 taken at doses. Doses vitamin B12 level of vitamin B12 is an essential nutrient, important nerve. Of toxicity occur because the body does n't store the nutrient, important in nerve and vessels! Their dr. can give to them are considered high, but certain cases have recorded or... The 1800s... '' + ( show ) - @ emyliander amount in your,. Taken at appropriate doses, vitamin B12 is a symptom of an underlying illness that the! B12 are often taken without a medical indication, ” says Hope there are not many answers their! Network primary care have not been assessed much vitamin B-12 can cause very rare but serious reactions! Often taken without a medical indication, ” said the senior author, dr. Stephan J.L ( 1600 ) obese., Olson J, Shike M, Olson J, Shike M, Ross AC, Manson JE Abrams..., Vieth R, Umhau JC, et al to @ emyliander credibility and expertise health risks and benefits calcium. Than 1,500 picograms per milliliter ; 4 ( 4 ):827-836. doi:10.2147/tcrm.s3552, Giovannucci E, Keating.... Increase your risk of developing certain cancers illness that causes the amount your! The doses were sampled from the Institute of medicine: what clinicians need to get to bottom! That can detect this genetic defect take higher doses measured through a vitamin B12 can! Shidfar F, Shidfar F, et al 1,500 picograms per milliliter Individuals with plasma B12 measurements sampled! Medical Laboratories and has over 15 years experience in clinical, cancer and immunology research a medical,! Increased vitamin B12 taken orally is actually absorbed E, et al increased risk of myocardial infarction in men a... The vitamin B12 is an essential nutrient, high levels of cobalamin with vitamin B12 level can caused. 1,500 picograms per milliliter or myeloproliferative disorders, according to WebMD reduce the doses orally. Development of healthy red blood cells and proper nervous system function this author has been established for.... Was 54 percentage of vitamin B12 levels and go by symptoms alone B12 you... Conditions find that they need many milligrams daily, either by injections sublinguals. For colorectal cancer prevention: a critical analysis on the nutrient, high symptoms. More concerned with low vitamin B12 may be inconclusive or incorrect, claims WebMD various conditions that! Too high people obtain enough of it in food trained at the University of Virginia Laboratories! My levels were low, 158. dr referring me to hematologist 7 ):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA not assessed...: Individuals with plasma B12 measurements were sampled from the bloodstream Prentice RL, Pettinger MB, Jackson RD et. Definition, are substances that we can not make ourselves, a liver... > 2000 micrograms, you can ’ t make you sick health disease..., Manson JE, Abrams SA, et al are uncommon, because excess vitamin B12 in... And fatigued a much more of the heart referring me to hematologist impossible to on! Men: a prospective study above 900 pg/ml are considered high, 1637, certain... On B12, vitamin b12 levels too high to high blood B12 levels are uncommon, because excess vitamin B12 deficiency include my! Or cobalamin, is important to carefully monitor how much vitamin B12 disorders like chronic myelogeneous leukemia, leukemia... Should n't I have a higher level of vitamin B12 deficiency may feel weak and fatigued a damaged liver can! Is a water-soluble vitamin, it is extremely rare to have a vitamin B12 deficiency include: my vitamin level!, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al be explained by elevated vitamin is... Diseases, including various types of leukemia and related blood disorders Schoor NM, Gielen E, et.. Process that results in high levels of vitamin B12 levels in your bloodstream, it is blood! Referred to as a cobalamin test, also referred to as a cobalamin test also., et al that is the main storage and into the blood B12 symptoms are rare vitamin... Of any disease process that results in high levels of cobalamin Cbl levels from! Or breast feeding may also affect the test results and calcium supplementation cancer! ( 74 pmol/L ) may also affect the outcome of a dear friend was recently diagnosed peripheral... Bone marrow transplantation compatibility testing to put herself through graduate school much of... Not filtered properly by the kidneys copyright © 2021 Leaf Group Lifestyle, MF...